Arteriovenous loops (AVL) of Corlett are used to provide recipient vessels for complex microsurgical reconstructions in vessel depleted lower limbs. They can be prone to thrombosis, injury during re-dissection, and possible steal phenomenon. We report an approach to improve safety and decrease dissection time in a delayed complex lower limb reconstruction.
Gene therapy is a promising treatment for protein deficiency disorders such as hemophilia B. However, low tissue selectivity and efficacy are limitations of systemic vector delivery. The authors hypothesized that selective transfection of rat superficial inferior epigastric artery flaps could provide systemic delivery of coagulation factor IX, preventing the need for systemic vector administration.